EMF Health-effects Research
Fetal rat brain ornithine decarboxylase (ODC) activity and polyamine levels following exposures to Iridium cell phone fields in late pregnancy
Unpublished but presented at a workshop in Washington, D.C. on Feb 4 2000
Department of Biochemistry, University of California, Riverside, CA 92521
From the amino acid ornithine, the enzyme ornithine decarboxylase (ODC) synthesizes highly charged, polycationic long chain polyamines: putrescine, spermidine and spermine. They are sensitive markers for external stimuli and are indicators for both growth and stress. They are essential in DNA synthesis.
Overexpression of ODC in initiated cells leads to tumor formation in the absence of any other promotors. ODC activity in cultured cells is sensitive to both ELF fields and to microwave fields with ELF modulation. We have tested effects of repeated, intermittent simulated exposure to IRIDIUM cell phone fields in late pregnancy on brain ODC activity and polyamine levels in Fischer 344 fetal rats. IRIDIUM signals use a Time Division Multiple Access (TD MA) modulation with 11 packets/sec at a carrier frequency of 1.6 GHz.
We performed an initial experiment and 1 replication (Cain et al. Proc 21st BEMS Annual Meeting, pp 126-127, 1999). Experimental conditions included cage-controls (5 litters, n=21), sham-exposed (5 litters, n=40); uterine exposures at SAR = 0.16 W/kg (3 litters, n=16); at uterine SAR = 1.6 W/kg (5 litters, n=40); and at uterine SAR 5.0 W/kg (4 litters, n=20). A near-field exposure system utilized 2 stacked acrylic platforms for simultaneously exposing and sham-exposing. Each had a central, vertically oriented antenna surrounded by 10 radial animal restraint tubes. Rats were positioned with their hindquarters toward the antenna for maximum uniformity in fetal dosimetry.
On Gestation Days (GDs) 18-21, timed-pregnant dams were exposed or sham-exposed fo r 2h/day. On GD21, dams were sacrificed and fetal cerebral and cerebellar ODC activity and polyamine levels of putrescine, spermidine and spermine determined.
Field exposures significantly decreased cerebral and cerebellar ODC activity compared to sham-exposed fetuses.
We noted no other effects of restraint on cerebral polyamines.
Further studies would evaluate
Additional Web Notes
The initial research was supported by Motorola Inc. However after this stage was reached, two requests for further funding were denied. Another institution, selected by Motorola, later asked Adey for assistance in performing a repetition of the study.
So they wanted to check his findings, but not to continue the primary research.